Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study.
Study Type
OBSERVATIONAL
Enrollment
60
The participants will receive a standardized meal for breakfast
University of Bern
Bern, Switzerland
RECRUITINGVOC Patterns over time as gallery plots
Gallery plots (3D visualization of retention index, drift time, ion current) from selected VOC peaks over time.
Time frame: During the study procedure (approximately 8 hours)
VOC Patterns over time as boxplots
Box plots from selected VOC peaks over time.
Time frame: During the study procedure (approximately 8 hours)
Capillary blood glucose
Correlation between capillary blood glucose and VOCs
Time frame: During the study procedure (approximately 8 hours)
Correlation between VOCs in breath intestinal microbiota
Correlation between VOCs in breath and intestinal microbiota species abundance
Time frame: day 1
Correlation between VOCs in breath oral microbiota
Correlation between VOCs in breath and oral microbiota species abundance
Time frame: day 1
Correlation between VOCs and subgroups
Wilcoxon signed-rank test will be used to explore if the patterns in VOCs differ between subgroup: people without diabetes, people living with T1D, and people living with T2D
Time frame: day 1 or 8 hours
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