Towards Improved Diagnostics for Suspected Platelet Function Disorders

Region Stockholm140 enrolled

Overview

This study aims to improve platelet function testing during bleeding investigations. To this end, the study will evaluate the diagnostic accuracy of novel platelet function tests in patients with confirmed or suspected platelet function disorders. Study participants will be recruited from patients that are referred to or treated at the Coagulation Unit, Karolinska University Hospital, and Pediatric Coagulation Unit, Astrid Lingren Children's Hospital.

Study Type

OBSERVATIONAL

Enrollment

140

Conditions

Platelet Function Disorder Platelet Disorder Thrombocytopathy

Eligibility

Sex: ALLMin age: 12 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria, known defects: * Known platelet function disorder under follow-up at Karolinska University Hospital (genetic or functional assay) * High likelihood of platelet function disorder (aberrant screening test with inheritance) * Family investigation for platelet disorder Exclusion Criteria, known defects:: * Antiplatelet or anticoagulant drugs * vWF:GPIb below 0.40 IU/mL * Hematocrit below 0.35 or above 0.50 * Other coagulation disorder Inclusion Criteria, suspected platelet function disorder: * Bleeding investigation at Karolinska University Hospital Exclusion Criteria, suspected platelet function disorder:: * Antiplatelet or anticoagulant drugs * vWF:GPIb below 0.40 IU/mL * Hematocrit below 0.35 or above 0.50 * Other coagulation disorder

Outcomes

Primary Outcomes

Platelet-thrombus formation on collagen surface

Whole-blood platelet-thrombus formation on collagen surface measured in a semi-automatic microchip flow chamber by a pressure sensor. Coagulation activation is inhibited.

Time frame: At study inclusion