This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
Participants who meet the diagnostic criteria for CRPS, aged 19\~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control). Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.
Study Type
OBSERVATIONAL
Enrollment
10
Seoul National University Hospital
Seoul, South Korea
RECRUITINGNumerical Rating Scale (NRS)
Intensity of pain (now, weekly avarege, weekly maximum)
Time frame: At the time of biopsy
Thermography
Thermography of the involved limb
Time frame: At the time of diagnosis
Quantitative Sensory Testing (QST)
Vibration Detection Threshold (VDT), Cold Detection Threshold (CDT)
Time frame: At the time of diagnosis
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