Analysis of CMTM6 Expression in Patients With Acute Myeloid Leukemia

University of Freiburg150 enrolled

Overview

In this study, we aim to investigate the expression of CKLF like MARVEL transmembrane domain containing 6 (CMTM6) in leukemia cells of patients with acute myeloid leukemia (AML). We will use peripheral blood samples and assess CMTM6 expression by flow cytometry and Western Blot.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Acute Myeloid Leukemia, Adult

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 18 years * primary diagnosis of acute myeloid leukemia * diagnosis results available * written informed consent * ability to understand the nature of the study and the study related procedures and to comply with them Exclusion Criteria: * age \< 18 years * lack of informed consent

Locations (1)

Medical Center- University of Freiburg

Freiburg im Breisgau, CA, Germany

Outcomes

Primary Outcomes

CMTM6 expression (FC)

CMTM6 expression on blasts/monocytes will be measured by flow cytometry

Time frame: At primary diagnosis

T cell activation (FC)

T cell activation and cytokine production will be measured by flow cytometry

Time frame: At primary diagnosis

Secondary Outcomes

CMTM6 expression (WB)

CMTM6 expression on blasts/monocytes will be measured by Western blot

Time frame: At primary diagnosis

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.