Impact of Circadian Rhythm on the Spread of Circulating Tumor Cells in Lung Cancer Patients

Inclusion Criteria: 1. Patient with histologically confirmed advanced NSCLC (inoperable stage 3 or 4) 2. Patient aged ≥ 18 years 3. Life expectancy \> 3 months 4. Patient naïve to treatment for NSCLC 5. Patient hospitalized at least one night for initiation of specific treatment (chemotherapy, radiotherapy, surgery, other...) 6. Patient with no other active cancer. Cancer history accepted if more than 3 years old and considered cured. 7. Patient affiliated to a Social Security scheme in France. 8. Patient having signed informed consent prior to inclusion in the study and prior to any specific study procedure. Exclusion Criteria: 1. Small-cell cancer or cancer with a majority small-cell contingent 2. Patient previously treated for NSCLC 3. Outpatient 4. Patient with active pathology such as sepsis or uncontrolled inflammatory syndrome 5. Any pathology contraindicating the sample collection procedures required by the study. 6. Pregnant or breast-feeding women. 7. Any psychological, family, geographical or sociological condition that makes it impossible to comply with the medical follow-up and/or procedures stipulated in the study protocol. 8. Patients deprived of their liberty or under legal protection (guardianship, legal protection).