Effectiveness and Safety of Topical Finasteride and Minoxidil Combination Compared to Topical Minoxidil for The Treatment of Male Androgenetic Alopecia

Indonesia University40 enrolled

Overview

A double-blind, randomized, controlled trial of 40 male patients with androgenetic alopecia was conducted. All subject were randomized to receive either combination of minoxidil 5% topical and finasteride 0,1% topical or minoxidil 5% topical

All subject were randomized to receive either combination of minoxidil 5% topical and finasteride 0,1% topical or minoxidil 5% topical The primary outcome was increase of the hair density and hair diameter (mean thickness) measured by trichoscan Measurements were done at baseline and every four weeks for twelve weeks. Additionally, side effects of therapy was also measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Androgenetic Alopecia

Interventions

FinasterideDRUG

finasteride topical 0,1%

MinoxidilDRUG

minoxidil topical 5%

Eligibility

Sex: MALEMin age: 18 YearsMax age: 59 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male aged from 18-59 years diagnosed with androgenic alopecia 2. Androgenic alopecia type III-V according to Hamilton-Norwood criteria 3. Willing to participate in this research by signing the consent form after receiving an explanation from the researcher 4. Willing to not cutting the hair nor coloring the hair during the study Exclusion Criteria: 1. Diagnosed with other infectious or inflammatory skin disease in the scalp 2. Using oral medications or vitamins that aim to increase the amount of hair in the last 1 month 3. Using topical medication that aim to increase the amount of hair in the last 2 weeks 4. Undergoing cosmetic procedure for AGA therapy such as low-level laser therapy (LLLT) procedures, platelet-rich plasma (PRP) injections, or microneedling within the last 3 months 5. Have sexual disorder such as decreased libido 6. Have a history of allergy or irritant contact dermatitis to the minoxidil and finasteride

Locations (1)

University Indonesia

Jakarta, Other (Non U.s.), Indonesia

RECRUITING

Outcomes

Primary Outcomes

Hair density

Density of the hair is the number of hair strands per square inch of the scalp measured by trichoscan