Dose of Remi in Children

Zhihong LU25 enrolled

Overview

Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, the effective dosage of remimazolam in pediatric patients is still unknown.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Anesthesia

Interventions

RemimazolamDRUG

remimazolam is given intravenously

Eligibility

Sex: ALLMin age: 3 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age from 3 to 12 years old * patients scheduled for surgery under general anesthesia Exclusion Criteria: * American Society of Anesthesiologists status \>=Ⅲ * Body mass index\>=28kg/m2 * patients who cannot cooperate with intravenous anesthesia induction * patients with risk of difficult airway * patients who are allergic to benzodiazepines * patients with delayed neurologic function

Outcomes

Primary Outcomes

half effective dosage

the dosage by which half of the patients will be sedated

Time frame: from injection of remimazolam to loss of consciousness, at an average of 5 minutes

Secondary Outcomes

95% effective dosage

the dosage by which 95% of the patients will be sedated

Time frame: from injection of remimazolam to loss of consciousness, at an average of 5 minutes

Data from ClinicalTrials.gov

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