Assessment of Serum Levels of Adenosine Deaminase and Immunoglobulin E in Patients With Chronic Spontaneous Urticaria

Sohag University90 enrolled

Overview

adenosine deaminase activity (ADA) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis. There is no previous studies that assessed ADA in chronic spontaneous urticaria (CSU) .

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Spontaneous Urticaria

Interventions

Adenosine deaminase serum levelDIAGNOSTIC_TEST

Adenosine deaminase will be measured by enzymatic (clorometric / kinetic) method (Diazyme laboratories, San Diego, California, USA).

IgE antibodies serum levelDIAGNOSTIC_TEST

Level of IgE will be measured by electrochemiluminesence immunoassay (ECLIA, automatic cobase immunoassay, Roche Diagnostics GmbH, Mannheim, USA).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients complaining of CSU and a group of age and sex-matched healthy controls (blood donors). Exclusion Criteria: * Pregnancy and lactation. * Patients with systemic diseases, especially those with autoimmune diseases and infections. * Patients with skin diseases. * Patients on medications such as antibiotics, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, anticonvulsants, penicillin, and combined oral contraceptives.

Outcomes

Primary Outcomes

Serum level of adenosine deaminase

Difference in serum level of adenosine deaminase between CSU group and control group

Time frame: 3 months

Serum level of IgE

Difference in serum level of IgE between CSU group and control group

Time frame: 3 months

Central Contacts

Ahmed M Ahmed, M.B.B.Ch

CONTACT

+201093593974 Dr.ahmed.elsheikh94@gmail.com

Ramadan Saleh, MD

CONTACT

+201005423054 salehr2010@yahoo.com

Data from ClinicalTrials.gov

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