Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCC

Inclusion Criteria: * The age at the time of enrollment is more than 18 years old and less than 70 years old, both male and female. * Histologically diagnosed as squamous cell carcinoma of the mouth, oropharynx, hypopharynx or larynx; preoperative evaluation can be surgically resected. * Have the following high-risk recurrence conditions as defined in the 8th edition of the American Joint Committee on Cancer \[AJCC\] Guidelines: a)HPV-negative disease, stage III, IVa, according to the head and Neck Tumor/lymph node/metastasis (TNM) guidelines; b)non-oropharyngeal HPV-positive disease, stages III, IVa, IVb, according to head and neck TNM guidelines. * No previous treatment for HNSCC. * Have at least one evaluable target lesion according to RECIST version 1.1 criteria. * The Eastern Cancer Cooperation Organization (ECOG) physical fitness score was 0 or 1. * Major organs have normal function, the following criteria are met: * The standard of blood routine examination（(not transfused or receiving component blood within 14 days prior to testing)：hemoglobin (HB) ≥ 9g/dL；absolute neutrophil count (ANC) ≥1.5×10\^9/L, platelets (PLT) ≥100×10\^9/L. * Biochemical examination: serum total bilirubin (TBIL) \<1.5 times the upper limit of normal value(ULN); aspartate aminotransferase (AST) and alanine aminotransferase (ALT)\<2.5 ULN; serum creatinine≤ULN and endogenous creatinine clearance\>50 mL/min (Cockcroft-Gault formula) Gault formula). * Signed written informed consent. * Adhere to the research protocol judged by the investigator. * female subjects of reproductive potential must have a negative serum pregnancy test prior to the first dose of the trial drug. * The male fertile patients and female fertile patients with pregnancy risk must consent to the use of 2 contraceptive methods (at least one of which is considered highly effective) throughout the study period. * Patients who are willing and able to follow visit schedules, treatment plans, laboratory tests, and other research procedures. Exclusion Criteria: * prior treatment with EGFR/PD-1/PD-L1/PD-L2/CD137/CTLA-4 antibodies(including ipilimumab) or activating or inhibitory agents targeting T-cell receptors. * Major surgery within 4 weeks before enrollment. * Proven allergic to EGFR monoclonal antibody, PD-1 antibody or its excipients. * Any active autoimmune disease or history of autoimmune disease (e.g., the following: interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism (can be included after effective hormone replacement therapy), etc; patients with vitiligo or asthma in complete remission in childhood may be included, adults patients with asthma who do not need any intervention and require medical intervention with bronchodilators may be included) . * Previous or co-existing malignancies (except those that have been cured and have survived cancer-free for more than 5 years, such as basal cell carcinoma of the skin, carcinoma in situ of the cervix, and papillary carcinoma of the thyroid). * Failure to control cardiac clinical symptoms or disease, e.g., the following: a) patients with NYHAII or above heart failure, b) unstable angina pectoris c) patients with myocardial infarction within 1 year, d) patients with clinically significant supraventricular or ventricular arrhythmias requiring clinical intervention. * Subjects requiring systemic treatment with corticosteroids (\> 10mg/ day prednisone efficacy dose) or other immunosuppressants within 14 days prior to administration of the study drug were allowed to use inhaled or topical steroids and adrenal hormone replacement at a dose\>10mg/day prednisone efficacy dose in the absence of active autoimmune disease. * Have active infections that require treatment. * Have a congenital or acquired immune deficiency (such as HIV infection), active hepatitis B (HBV-DNA≥10\^3 copy number/ml), or hepatitis C (hepatitis C antibody positive and HCV-RNA above the lower detection limit of analytical methods). * The patient has received other treatment before. * Had received live vaccine within 4 weeks prior to starting study treatment. * A known history of psychotropic substance abuse, alcohol or drug use. * Pregnant or lactating women. * In the investigator's judgment, the subjects had other factors that might have led to their forced discontinuation of the study, such as other serious medical conditions (including mental illness) requiring concomitant treatment, serious abnormalities in laboratory test values, or family or social factors that might have affected the safety of the subjects or the circumstances of the trial data collection. * HNSCC Patients with T1/T2 or N0/N1. * oral cancer, larynx cancer, hypopharyngeal cancer withT4b or N3 and P16-oropharyngeal cancer. * Have active pulmonary tuberculosis. * Serious infections (including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia) that occurred within 4 weeks prior to initiation of study treatment. * Had received systemic immunostimulatory drugs (including but not limited to interferon or interleukin-2 \[IL-2\]) within 4 weeks prior to initiation of study therapy or remained within 5 drug half-lives (choice the longer of the two). * Patients with recurrent peptic ulcers (e.g., gastric ulcers, duodenal ulcers), who have a history of peptic ulcer complications such as perforation, bleeding, obstruction, etc., or who have been assessed by clinicians as having a higher risk of complications.