The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes. The primary aims are to determine the effect PAC's have on glycemic variability and the concentrations of circulating biomarkers of inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
160
A commercially available PAC with a true HEPA filter will be used. Unit will be placed in the bedroom and used continuously (24 hours/day) for a total of 4 weeks.
Uses the same model as the experimental PAC that is identical in appearance and sound with the HEPA filter removed . Unit will be placed in the bedroom and used continuously (24 hours/day) for a total of 4 weeks.
NYU Langone Medical Center
New York, New York, United States
RECRUITINGPercent Change in A Continuous Glucose Monitor (CGM) Coefficient of Variation (CV)
A CGM will be placed at baseline to continuously measure glucose, which will then be used to assess glycemic variability at the end of 4 weeks post-intervention. This outcome will be measured using the following equation: ((\[post-intervention\]-\[pre-intervention\]))/(\[pre-intervention\])\*100%
Time frame: Baseline, Week 4
Percent Change of C-reactive Protein (CRP) Biomarkers
This outcome will be measured using the following equation: ((\[post-intervention\]-\[pre-intervention\]))/(\[pre-intervention\])\*100%
Time frame: Baseline, Week 4
Percent Change in Concentration of Interleukin-6 (IL-6) Biomarkers
This outcome will be measured using the following equation: ((\[post-intervention\]-\[pre-intervention\]))/(\[pre-intervention\])\*100%
Time frame: Baseline, Week 4
Percent Change in Concentration of Tumor Necrosis Factor-alpha (TNFα) Biomarkers
This outcome will be measured using the following equation: ((\[post-intervention\]-\[pre-intervention\]))/(\[pre-intervention\])\*100%
Time frame: Baseline, Week 4
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