The goal of the proposed observational, multi-site study is to use fNIRS neurophysiological data recorded during a battery of tasks to detect MCI within a cohort consisting of patients and age-matched healthy controls. Furthermore, the investigators aim to explore whether they can measure the severity of MCI symptoms in the patient population. If successful, this approach enables clinicians to track the disease at its source-the brain; possibly allowing for earlier detection of MCI and its progression, and ultimately more efficient interventions.
Study Type
OBSERVATIONAL
Enrollment
133
Kernel Flow2 measurements.
The Research Center of Southern California
Carlsbad, California, United States
BrainHealth Solutions
Costa Mesa, California, United States
The Research Center of Southern California
Escondido, California, United States
Kernel
Los Angeles, California, United States
Brain hemodynamic activity with TD-fNIRS
This includes changes in the concentration of oxygenated and deoxygenated hemoglobin as measured by the change in light absorption.
Time frame: About 1 hour during the study visit
Optical properties of the brain with TD-fNIRS
This measures how much light is absorbed at different points on the head.
Time frame: About 1 hour during the study visit
Physiological features with TD-fNIRS
This includes cardiac measures, such as heart rate (HR) and heart rate variability (HRV).
Time frame: About 1 hour during the study visit
Mini-Mental State Evaluation (MMSE)
Clinician-administered screening tool used to systematically and thoroughly assess mental status through five areas of cognitive function: orientation, registration, attention and calculation, recall, and language. Patient cohort only. Scores range between 0-30. A score of 25 or higher is classed as normal. If the score is below 24, the result is usually considered to be abnormal, indicating possible cognitive impairment.
Time frame: Within 6 months of the study visit
Mini-Cog
A fast and simple screening test to help detect cognitive impairment in its early stages that will be used to confirm normal cognitive function in the control group. Healthy control cohort only. Scores range between 0-5. Participants who score 0-2 are considered to indicate higher likelihood of cognitive impairment.
Time frame: About 30 minutes during the study visit
Geriatric Depression Scale (Short Form)
15-item self report measure of depression in older adults. Scores range between 0-15. Higher scores indicate high severity of depression.
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Syrentis Clinical Research
Santa Ana, California, United States
The Research Center of Southern California
Temecula, California, United States
Time frame: About 30 minutes during the study visit
General Anxiety Disorder
Seven-item self report measure used to assess participant anxiety. Scores range between 0-21. Higher scores indicate high severity of anxiety.
Time frame: About 30 minutes during the study visit
Apathy Evaluation Scale
18-item self-rated measure used to assess and quantify emotional, behavioral, and cognitive aspects of apathy. Scores range between 18-72. Higher scores indicate high severity of apathy.
Time frame: About 30 minutes during the study visit
Alzheimer's Disease Cooperative Study Activities of Daily Living for Mild Cognitive Impairment (ADCS ADL-MCI)
15-item self report measure used to assess performance of activities of daily life. Scores range between 0-45. Higher scores indicate declining cognition.
Time frame: About 30 minutes during the study visit