Primary Liver Cancer Early Detection

Inclusion Criteria: Inclusion Criteria for all participants * Individuals aged 18-74 years old * Individuals capable of giving signed and legally effective informed consent voluntarily Inclusion Criteria for liver cancer participants: * Individuals newly diagnosed with or suspected of having liver cancer (including hepatocellular carcinoma \[HCC\], intrahepatic cholangiocarcinoma \[ICC\], and combined hepatocellular-cholangiocarcinoma \[cHCC-CCA\]). * Individuals without any anti-cancer therapy prior to blood sample collection. Inclusion Criteria for participants with benign liver diseases: * Individuals newly diagnosed as benign liver diseases before blood sample collection * Individuals without curative treatment for the disease before blood sample collection Inclusion Criteria for participants with interfering cancers: * Individuals diagnosed with or suspected of having interfering cancer * Individuals without any anti-cancer therapy prior to blood sample collection Inclusion Criteria for healthy participants: * No cancer-related or other clinical symptoms 30 days prior to blood sample collection * No prior history of benign liver diseases Exclusion Criteria: Exclusion Criteria for All the Participants: * Individuals cannot provide blood samples at the study-specified blood collection sites * Pregnancy or lactating women * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 7 days prior to blood sample collection * Recipients of anti-infective treatment within 14 days prior to blood sample collection * Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer * Individuals with a history of malignant tumor Exclusion Criteria for liver cancer participants: * Known prior or current diagnosis of other types of malignancies or multiple primary cancers * No confirmed diagnosis of liver cancer after blood sample collection Exclusion Criteria for participants with benign liver diseases: * Individuals with a confirmed diagnosis of a malignant tumor or precancerous lesion * Individuals who cannot be diagnosed as having benign liver diseases after blood sample collection Exclusion Criteria for participants with interfering cancers: * Known prior or current diagnosis of other types of malignancies or multiple primary cancers * No confirmed diagnosis of any type of interfering cancers after blood sample collection Exclusion Criteria for healthy participants: * Prior or ongoing treatment of cancers within 3 years prior to blood sample collection * Clinically significant or uncontrolled comorbidities