Continuous Norepinephrine Administration and Blood Pressure Stability During Anesthetic Induction

Universitätsklinikum Hamburg-Eppendorf72 enrolled

Overview

This is a randomized trial investigating whether continuous norepinephrine administration via an infusion pump - compared to manual bolus administration - increases blood pressure stability within the first 15 minutes of anesthetic induction in non-cardiac surgery patients. The secondary endpoints area under a MAP of 65, 60, 50, and 40 mmHg \[mmHg × min\], cumulative duration of a MAP \<65, \<60, \<50, and \<40 mmHg \[min\], area above a MAP of 100, 110, 120, and 140 mmHg \[mmHg min\], cumulative duration of a MAP \>100, \>110, \>120, and \>140 mmHg \[min\] and cumulative dose of norepinephrine indexed to body weight \[μg/kg\] within the first 15 minutes of anesthetic induction will be assessed.

not provided

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Blood Pressure Perioperative Hypotension

Interventions

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 45 years * American Society of Anesthesiologists physical status II-IV * scheduled for elective major non-cardiac surgery under general anesthesia * continuous intraarterial blood pressure monitoring using a radial arterial catheter for clinical indications not related to the trial * sinus rhythm Exclusion Criteria: * Clinical indication to use a continuous norepinephrine infusion via an infusion pump during anesthetic induction * Need for femoral artery catheterization * History of intracranial bleedings or aneurysms * Patients who are incapable of giving consent * Pregnancy

Outcomes

Primary Outcomes

Blood pressure stability

Generalized average real variability (gARV) of mean arterial pressure (MAP) within the first 15 minutes of anesthetic induction \[mmHg/min\]; the gARV is the sum of absolute values of the differences between neighboring measurements for all measurements divided by the total measurement duration in \[mmHg/min\].