Dermatitis Herpetiformis Refractory to Gluten Free Diet

N/AEnrolling By InvitationNCT05998291

Tampere University Hospital23 enrolled

Overview

The main purpose of the study is to find out 1. the natural course of refractory dermatitis herpetiformis and the development of possible complications 2. the strictness of gluten-free diet treatment in refractory dermatitis herpetiformis

Refractory dermatitis herpetiformis refers to dermatitis herpetiformis unresponsive to gluten-free diet therapy. So far, there is very little knowledge on the course of the disease and the causes and prognosis of refractory celiac disease. Study patients with refractory dermatitis herpetiformis will be recruited. As a control material dermatitis herpetiformis patients with good response to gluten-free dietary treatment will be recruited.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dermatitis Herpetiformis

Interventions

Assessment of prognosis of refractory dermatitis herpetiformis. No interventionOTHER

Assessment of prognosis of refractory dermatitis herpetiformis. No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Study patients: * Dermatitis herpetiformis diagnosis * Dermatitis herpetiformis rash not responding to a strict gluten-free diet after at least 3 years Control patients: * Dermatitis herpetiformis diagnosis * Dermatitis herpetiformis with good response to a gluten-free diet Exclusion Criteria: Study patients: -Not following strict gluten-free diet Control patients: -Not following a strict gluten-free diet

Locations (1)

Tampere University Hospital

Tampere, Finland

Outcomes

Primary Outcomes

Clinical prognosis

Occurrence of complications

Time frame: Baseline

Secondary Outcomes

Dietary adherence GIP test, CDAT, TG2, TG3 and Ema antibodies, anamnesis

The strictness of gluten-free diet (GIP test)

Time frame: Baseline

Data from ClinicalTrials.gov

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