The primary purpose of this study is to compare the single-dose pharmacokinetics (PK) of casdatifan tablet versus the casdatifan capsule, and to evaluate the effect of food on the single-dose PK of casdatifan tablet in healthy adult volunteers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Administered as specified in the treatment arm
Celerion, Inc.
Lincoln, Nebraska, United States
Area Under the Plasma Drug Concentration-Time Curve (AUC)
Time frame: Predose, Up to 168 hours postdose
Maximum Concentration (Cmax)
Time frame: Predose, Up to 168 hours postdose
Time to Maximum Concentration (Tmax)
Time frame: Predose, Up to 168 hours postdose
Terminal Half-Life Time (t1/2)
Time frame: Predose, Up to 168 hours postdose
Apparent Total Plasma Clearance (CL/F)
Time frame: Predose, Up to 168 hours postdose
Apparent Volume of Distribution During the Terminal Elimination Phase (Vz/F)
Time frame: Predose, Up to 168 hours postdose
Number of Participants With Adverse Events
Time frame: Up to 10 weeks
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