The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women

Chang Gung Memorial Hospital76 enrolled

Overview

A single-blind, randomized, and probiotic-treatment including adult women with vaginitis and/or HPV positive. After oral probiotics, all participants will be followd-up cervical swabs and vaginal microbiome alteration till the end of the study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome

Interventions

probiotic:Lactobacillus crispatusDIETARY_SUPPLEMENT

We seek to observe that probiotic supplement(arm A) can improve vagina microbiome distribution by comapred to placebo group(arm B) in our study.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed as vaginal viginitis * willing to sign permit * willing to regular follow up Exclusion Criteria: * Pregnant * Virgin * Severe cervix pathology CINII or CIN III * Confirmed cervical cancer * under long term antibiotics due to other physical condition

Locations (1)

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

RECRUITING

Outcomes

Primary Outcomes

improvement alteration of vaginal microbiome

16s rRNA

Time frame: 3 months

Data from ClinicalTrials.gov

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