Safety, Reactogenicity and Immunogenicity of a Venezuelan Equine Encephalitis DNA Vaccine Candidate Administered by Jet Injection

Inclusion Criteria: * Healthy adults, male or female. * Ages at least 18 at the start of the study and no greater than 49 years of age on Day 1 of vaccination. * Participants must be available for all visits and for the complete duration of the study. * Participants must, in the opinion of the Investigator or person obtaining consent, understand the information provided and be capable of providing informed consent. * Women of child bearing potential (WOCBP) must have a negative pregnancy test and be willing to use an effective method of contraception: oral contraception, diaphragm, cervical cap, intrauterine device, condom, or be anatomically sterile (in self or partner) from the date of screening until at least 6 months after the last vaccination. * If subject is a sexually active male, must be willing to use an effective method of contraception (such as condoms or be anatomically sterile) from screening until 6 months after the last vaccination. Exclusion Criteria: * Clinically relevant abnormality on history or examination including a history of immunodeficiency or use of systemic corticosteroids, immunosuppressive, anticancer, or other medications considered to be significant by the designated trial physician in the last 6 months. * Any acute or chronic medical condition requiring care of a physician (e.g., diabetes, coronary artery disease, rheumatologic illness, malignancy, substance abuse) that, in the opinion of the Investigator, would preclude participation. * Any of the following laboratory parameters with abnormal values that are moderate in severity: hematology (hemoglobin, absolute neutrophil count, absolute lymphocyte count, platelets); urinalysis; biochemistries (total bilirubin, creatinine, AST, ALT). * If female, pregnant, lactating, or planning pregnancy within 6 months of the final vaccination. * Receipt of a blood transfusion or blood products 6 months prior to enrollment. * Participation in another clinical trial of an investigational product currently or within the past 12 weeks or expected participation during the study. * History of severe local or systemic reactions to vaccination or a history of severe allergic reactions. * History of Guillain-Barre syndrome. * Confirmed diagnosis of HBV infection (surface antigen positive, HBsAg); Hepatitis C infection (HCV Ab positive); HIV infection, or active syphilis. * History of grand mal epilepsy, or currently taking anti-epileptics. * Any condition associated with prolonged bleeding time, which would contraindicate skin or muscle injection. * Abnormal ECG finding that, in the opinion of the Investigator, excludes the subject from participating. * History of syncope or history of a fainting episode within one year of study entry. * Extensive tattoos or markings covering the eligible sites of administration (the skin or muscle of the upper left and right deltoid muscles). * Presence of any surgical/traumatic metal implants, or significant scar tissue that may impair appropriate injection at the eligible sites of administration (skin or muscle of the upper left and right deltoid muscles). * In the opinion of the Investigator, is unlikely to comply with the protocol. * As confirmed/reported by the study subject, a history of: exposure to Venezuelan Equine Encephalitis Virus (VEEV) or related alphavirus; prior immunization with an alphavirus replicon-based vaccine; prior immunization with a live-attenuated alphavirus vaccine; prior immunization with an inactivated alphavirus vaccine. * A history of encephalitis as confirmed/reported by the study subject. * Prior immunization against VEEV or related alphavirus or encephalitis, as confirmed/reported by the study subject. * History of alcohol abuse, illicit drug use, physical dependence on any opioid, or any history of drug abuse (excluding marijuana) or addiction within 12 months of screening. * Involved in the planning or conduct of the study.