Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation

The Third People's Hospital of Hangzhou100 enrolled

Overview

The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are: * 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients; * 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Dermatomyositis Myocardial Repolarization Inflammation

Interventions

diseaseOTHER

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form. Clinical diagnosis of Dermatomyositis. Exclusion Criteria: Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women. Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc. Patients with severe lack of case data.

Outcomes

Primary Outcomes

QTc, Tp-e interval, and Tp-e/QT ratio were increased in DM patients.

Time frame: November 2011 to November 2022

the Tp-e interval and Tp-e/QT ratio were positively correlated with Inflammation.