Nutraceutical lipid-lowering interventions are becoming increasingly popular, particularly among patients who are intolerant or refractory to prescription statins, or who desire alternative non-conventional pharmacological treatment to manage their dyslipidaemia, whether they previously experienced statin intolerance or not. A growing body of preclinical and clinical evidence suggest that the amla (Emblica officinalis) red yeast rice (RYR), olive and walnut leaf extracts posses consideable hpolipidaemic pharmacological effects.
The present exploratory study aimed to assess the safety, efficacy, and patient's satisfaction of a combined supplementation of amla, red yeast rice, olive, and walnut leaf extracts (Cholesfytol NG®) on total cholesterol (TC), low-density lipoprotein - cholesterol (LDL-C), high-density lipoprotein - cholesterol (HDL-C), non-high-density lipoprotein - cholesterol (non-HDL-C), remnant cholesterol (RC) and triglycerides (TG) in hyperlipidaemic patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
221
General Practitioner (GP) prescribed oral Cholesfytol NG®) supplement
Cliniques universitaires St-Luc and Institut de Recherche Expérimentale et Clinique (IREC), KU Leuven
Leuven, Belgium
Change in blood lipid profile
Decrease in blood total cholesterol (TC) concentration
Time frame: 2-months
Change in blood lipid profile
Decrease in blood low-density lipoprotein - cholesterol (LDL-C) concentration
Time frame: 2-months
Change in blood lipid profile
Decrease in blood triglycerides (TG) concentration
Time frame: 2-months
Change in blood lipid profile
Decrease in blood non-high density lipoprotein - cholesterol (non-HDL-C) concentration
Time frame: 2-months
Decrease in blood lipid profile
Change in blood remnant cholesterol (RC) concentration
Time frame: 2-months
Rate of side effects
Number of patients reporting myalgia
Time frame: 2-months
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