Phase 1/2 Clinical Study of HRS-4357 in Patients With Advanced Prostate Cancer

Inclusion Criteria: 1. Voluntary participation in this clinical trial, understanding of the study procedures and being able to sign the informed consent form in writing; 2. Male, age ≥18 years; 3. ECOG score 0 - 1; 4. Histologically and/or cytologically confirmed adenocarcinoma of the prostate; Exclusion Criteria: 1. Spinal cord compression with clinical symptoms, or clinical symptoms and/or imaging findings suggesting imminent spinal cord compression. 2. Severe urinary incontinence, hydronephrosis, severe micturition dysfunction, etc. Note: Subjects with bladder outflow obstruction or urinary incontinence that can be controlled by the best available standard of care (including pads, drainage, etc.) are eligible to participate in the study. 3. Active syphilis infection. 4. Known hypersensitivity to components of the study drug or its analogues.