Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. The significance of the enteral micobiome on cardiovascular mortality of patients with cardiogenic shock is still not known. This study aims to provide a deeper understanding of the role of the enteral microbiome and microbiome dependent metabolites in mortality and disease progression of patients with cardiogenic shock.
Study Type
OBSERVATIONAL
Enrollment
40
No intervention: observational study
University Hospital Essen
Essen, North Rhine-Westphalia, Germany
Correlation between enteral microbiome composition and mortality
Stool samples are collected and clinical evaluation will be performed at below mentioned time points
Time frame: Sampling will be performed within 24 hours of onset of cardiogenic shock and clinical evaluation will be performed after 1 month
Correlation between TMAO serum level and mortality
Blood samples are collected at below mentioned time points
Time frame: Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3
Correlation between SCFA serum level and mortality
Blood samples are collected at below mentioned time points
Time frame: Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3
Correlation between inflammatory profile (CRP, PCT, Interleukin panel) and mortality
Blood samples are collected at below mentioned time points
Time frame: Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3
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