The goal of this interventional study is to test whether sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce the effects of high dietary sodium intake in patients with type 2 diabetes. Participants will undergo a dietary intervention consisting of a week of high-sodium diet, followed by a week of low-sodium diet. At the end of each week the patients will undergo: * 24-h ambulatory blood pressure measurement; * 24-h urine collection; * bioimpedance analysis for body composition determination; * blood and urine tests. The study will compare patients treated with SGLT2i and patients not treated with SGLT2i to test whether the treatment reduces the effects of high sodium intake on blood pressure, body composition and biochemical variables.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
Participants will undergo a dietary intervention consisting of a week of high-sodium diet (4800 mg/day), followed by a week of low-sodium diet (1200 mg/day).
Azienda Ospedaliero-Universitaria Pisana
Pisa, PI, Italy
RECRUITING24-hour Blood Pressure
Systolic and diastolic blood pressure will be measured by 24-h ambulatory blood pressure monitoring
Time frame: 2 weeks
Sodium excretion
24-hour sodium excretion will be measured by urine collection
Time frame: 2 weeks
Hydration state
Hydration state with extra- and intracellular water estimation will be measured by bioimpedance
Time frame: 2 weeks
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