This is a multicenter, retrospective clinical study, in patients with brucellosis, to analyze the clinical characteristics, complications, and the impact of different treatment options on long-term prognosis of patients with brucellosis. All hospitalized patients diagnosed with brucellosis between 2016 and 2021 were included from the electronic medical record systems of eight centers, collecting demographics, hospitalization information, clinical information, laboratories, imaging studies, treatment regimens, and disease outcome and other information.
Study Type
OBSERVATIONAL
Enrollment
200
Guangshui First Peoples Hospital
Guangshui, Hubei, China
Huanggang Central Hospital
Huanggang, Hubei, China
People's Hospital of Luotian County
Huanggang, Hubei, China
People's Hospital of Macheng city Affiliated Hospital of Hubei Univerciy of science and technology
Clinical characteristics
The electronic medical record system was used to collect patients' symptoms from baseline (admission) to 24 months, including initial symptoms, constitutional symptoms and signs \[fever (maximum temperature, duration), hyperhidrosis, muscle/joint soreness, fatigue, hepatomegaly, splenomegaly, testicular enlargement, oophoritis, lymphadenopathy (location and size), others\].
Time frame: 2 year
Complication rate
Electronic medical record system was used to collect the complications of patients from baseline (admission) to 24 months, and the incidence of complications within 2 years was calculated. Complications include osteoarticular system (sacroiliitis, spondylitis, peripheral arthritis, osteomyelitis, bone destruction, etc.) that may be related to brucellosis, Genitourinary system (orchitis, epididymitis, oophoritis, glomerulonephritis, renal abscess, etc.), central nervous system (peripheral neuropathy, meningoencephalitis, mental symptoms, cranial nerves, chorea, etc.), skin (maculopapular rash, Cyst, Stevens-Johnson syndrome, etc.), respiratory system (pleural effusion, pneumonia, etc.), blood system (leukocyte increase or decrease, platelet deficiency, etc.), cardiovascular system (endocarditis, vasculitis, myocarditis wait). Diagnostic tests for complications include laboratory tests (blood routine, etc.), echocardiography, imaging tests (X-ray, ultrasound, high-resolution CT)
Time frame: 2 year
Survival rate
The 1-year survival rate and 2-year survival rate were calculated.
Time frame: 1 year,2 years
Disease outcome (cured, improved, not cured, progress, relapse, death)
The electronic medical record system was used to collect the disease outcomes of patients from baseline (admission) to 24 months.
Time frame: 2 year
Etiological characteristics (B.melitensis [1, 2, 3 subtypes], B.abortus[1-9 subtypes], B.suis [1-5 subtypes], B.canis)
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Macheng, Hubei, China
Qianjiang Central Hospital
Qianjiang, Hubei, China
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
Xianning Central Hospital
Xianning, Hubei, China
Yichang Third Peoples Hospital
Yichang, Hubei, China
Etiologic characteristics were collected from baseline (admission) through 24 months with the use of an electronic medical record system. The distribution of pathogens was analyzed, and the relationship between different pathogenic characteristics and long-term prognosis (disease outcome) was evaluated.
Time frame: 2 year
Number of patients with severe brucellosis (ICU number)
The electronic medical record system was used to collect the proportion of patients admitted to ICU from baseline (admission) to 24 months, and the proportion of patients admitted to ICU was calculated.
Time frame: 2 year
antimicrobial therapy
The electronic medical record system was used to collect the treatment options of patients from baseline (admission) to 24 months, and the impact of different treatment options on prognosis (disease outcome) was evaluated.
Time frame: 2 year
Hospital costs
The electronic medical record system was used to collect the hospitalization expenses of patients, and the average hospitalization cost was calculated.
Time frame: 2 year