DOTr/DOTa Algorithm Guidance for Refractory Solid Tumors

Inclusion Criteria: 1. The subjects must be able to understand the procedures and methods of this study, be willing to strictly follow the clinical trial protocol to complete this trial, and voluntarily sign a written informed consent form; 2. Patients aged ≥ 18 years old; 3. Solid tumor patients who are depleted of standard treatment or unable to tolerate standard treatment regimens; 4. According to the RECIST solid tumor efficacy evaluation criteria, there should be at least one measurable lesion; 5. ECOG PS score 0-4 (3-4 score only for patients caused by tumor); 6. The expected survival period is not less than 12 weeks; 7. Women of childbearing age must have a Pregnancy test (serum) within 7 days before enrollment, and the result is negative, and are willing to use appropriate methods of contraception during the test period and within 8 weeks after the last administration of the test drug; 8. The subjects voluntarily joined this study, signed an informed consent form, had good compliance, and cooperated with follow-up; 9. If the main organs function normally, they meet the following standards: The blood routine examination standard must comply with (no blood transfusion or blood products within 14 days, no correction using G-CSF or other hematopoietic stimulating factors): Hb ≥ 90g/L; ANC ≥ 1.5 × 109/L; PLT ≥ 90 × 109/L;Biochemical examination must meet the following standards: TBIL ≤ 1 × ULN; ALT, AST ≤ 1.5 × ULN; ALP ≤ 2.5 × ULN; BUN and Cr ≤ 1.5 × ULN; Color Doppler echocardiography: left ventricular Ejection fraction (LVEF) ≥ 50%. Exclusion Criteria: 1. Severe heart disease or discomfort that cannot be treated; 2. Those who suffer from mental illness or abuse of psychotropic substances and are unable to cooperate; 3. Pregnant or lactating female patients; 4. Participating in other clinical trials at the same time; 5. Researchers believe that individuals are not suitable for enrollment.