The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of of dietary supplementation with a pre-probiotic on patient- and clinician-reported outcomes, and brain tissue metabolism in patients with post-covid fatigue syndrome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
32
Combination of pre-probiotic
Inert compound
Applied Bioenergetics Lab at Faculty of Sport and PE
Novi Sad, Vojvodina, Serbia
Fatigue
Level of fatigue as assessed by the Multidimensional Fatigue Inventory (MFI)
Time frame: Change from baseline fatigue at 3 months
Brain creatine
Magnetic resonance spectra for brain creatine concentrations
Time frame: Change from baseline brain creatine concentrations at 3 months
Patient-reported symptoms
Scale of symptoms assessed by Visal Analog Scales (VAS), minimum 0 maximum 10; higher scores mean a worse outcome
Time frame: Change from baseline fatigue at 3 months
Time to exhaustion
Running time to exhaustion during incrementaltestontreadmill
Time frame: Change from baseline time to exhaustion at 3 months
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