An Observational Cohort Study to Describe and Compare the Use of Darolutamide, Enzalutamide and Apalutamide and How Well These Work in Men With Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) in Real World Settings

Bayer1,375 enrolled

Overview

This is an observational cohort study in men with non-metastatic castration-resistant prostate cancer who received their usual treatment, which is 'Androgen receptor inhibitors' (ARIs) including darolutamide, enzalutamide, and apalutamide. The main purpose of this study is to collect data on the length of time men with nmCRPC continued treatment with darolutamide, enzalutamide, or apalutamide as prescribed by their doctors. Researchers will only include men who had not been treated with any new type of medication that blocks the action of hormones. The data will come from an electronic health record database called Precision Point Specialty (PPS) Prostate Cancer Electronic Medical Record (EMR) for men in the United States of America. EMR data will be verified and supplemented via patient chart review. Data collected will be from January 2019 to September 2023. .

Study Type

OBSERVATIONAL

Enrollment

1,375

Conditions

Non-metastatic Castration-resistant Prostate Cancer

Interventions

ApalutamideDRUG

Decision by the treating physician

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Men diagnosed with prostate cancer. 2. Diagnosis of nmCRPC prior to or within 90 days after the first ARI treatment initiation 3. Treatment with Darolutamide, Enzalutamide, or Apalutamide initiated for the first time 4. Age ≥ 18 years at treatment start 5. At least 6 months of Electro-Medical-Record activity after the treatment start unless the patient died earlier than 6 months. Exclusion Criteria: 1. Evidence of metastatic disease before or 30 days after treatment start 2. Prior history of other primary cancers