Hyponatremia Volume Status Analysis by Point-of-care Ultrasound

N/AActive Not RecruitingNCT06013800

Universidad Veracruzana80 enrolled

Overview

This observational study aims to analyze the time of correction of hyponatremia in patients within an internal medicine ward. The researchers will assess volume status using both clinical evaluation and point-of-care ultrasound. Patients will be categorized based on whether they have the same volume status determined clinically and by ultrasound or a different status between the two methods. By tracking sodium levels daily until normalization, the study will compare the time of hyponatremia correction between the two groups.

The main question it aims to answer are What is the time of correction of hyponatremia by assessing the volume status clinically or by point of care of ultrasound?. Participants will be asked to participate in the study and they will be receive a volume status by a portable ultrasound. If they have the same volume status clinically and by point of care ultrasound they will be referred as group 1. If they have a different volume status clinically or by point of care ultrasound they will be referred as group 2. Researchers will follow the patients by measuring the sodium levels daily until they reach normal sodium levels ( \>135mEq/L) and will compare group 1 and group 2 with a survival analysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hyponatremia Water-Electrolyte Imbalance

Interventions

Measurement of sodium levelsOTHER

Patients will get measurements of sodium levels daily in the first 48 hours, then daily or every other day until normal sodium levels (\>135mEq/L).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age greater or equal to 18 years * Hypotonic hyponatremia (less than 275mosm/kg) calculated by the following formula (2 Na+Glucose/ 18) Exclusion Criteria: * Patients who are critically ill with ventilatory support. * Patients with clinical signs suggestive of hypovolemia and have a documented history of aortic insufficiency or show mitral insufficiency during POCUS (Point-of-Care Ultrasound).

Locations (1)

Hospital Regional B Veracruz Alta Especialidad

Veracruz, Mexico

Outcomes

Primary Outcomes

Rate of participants with sodium level >135mEq/L

Rate of Achieving a Normal Sodium Level (\>135mEq/L) per Participant: This information will be visually represented through Group 1 and Group 2 using a Kaplan-Meier curve. Subsequently, the data will be evaluated using the Log-Rank test or the Breslow test for statistical significance.

Time frame: Baseline, everyday up to 30 days

Secondary Outcomes

Assessment of clinical variables associated with corrected sodium levels

To analyze whether the relationship between point-of-care ultrasound-assessed volume status and clinical variables-such as hypertonic saline administration, chronic liver disease, diuretic use, active cancer, type of hospital admission, severity of hyponatremia, and antidepressant use-influences corrected sodium levels.

Time frame: Baseline, up to 30 days

Data from ClinicalTrials.gov

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