Complications and Recurrences After Mohs Micrographic Surgery and Slow Mohs

N/AActive Not RecruitingNCT06014619

Maastricht University Medical Center500 enrolled

Overview

Mohs micro-graphic surgery (Mohs) is a tissue-sparing, surgical treatment for different types of skin cancer (e.g. basal cell carcinoma, squamous cell carcinoma, lentigo maligna (melanoma). It is a procedure performed with frozen sections. Slow Mohs, a variant of micro-graphic surgery, is performed by formalin fixation and paraffin-embedded sections. Both in Mohs and Slow Mohs tumor margins are assessed to achieve complete removal. This study aims to investigate the clinical presentation and outcomes (i.e. complications and recurrence rates) in patients treated with Mohs or Slow Mohs in the dermatology department of the Maastricht University Medical Center+ in Maastricht, the Netherlands.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Skin Cancer Complication Complication of Surgical Procedure Complication,Postoperative Recurrence Recurrent Disease Cutaneous Squamous Cell Carcinoma

Interventions

Mohs surgeryPROCEDURE

Treatment of a skin disease by Mohs micrographic surgery technique (frozen sections).

Slow Mohs surgeryPROCEDURE

Treatment of a skin disease by Slow Mohs technique (formalin fixation and paraffin-embedded sections).

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with a cutaneous lesion with an indication for Mohs micrographic surgery or Slow Mohs * patients who received a treatment with either Mohs or Slow Mohs between 1 july 2017 and 1 july 2023 at the dermatology department of the Maastricht University Medical Center+. Exclusion Criteria: * None.

Outcomes

Primary Outcomes

Incidence of complications

The incidence of complications after Mohs and Slow Mohs, expressed as absolute numbers and percentages.

Time frame: Within 1 month after completion of the surgical intervention.

Incidence of recurrence

The incidence of complications after Mohs and Slow Mohs, expressed as absolute numbers and percentages. Recurrence is defined as disease relapse after completion of treatment.

Time frame: Up to 5 year after completion of the surgical intervention.

Secondary Outcomes

Hazard ratio of predisposing factors for complications

Predisposing factors (patient- and tumor characteristics) for complications after Mohs and Slow Mohs, expressed in Hazard Ratio's and 95% confidence intervals. It is not possible to define the predisposing factors in advance, because this is currently unknown. We hypothesize the presence of diabetes, tobacco use and medication use to be predisposing factors for complications.