Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer

Inclusion Criteria: 1. Aged 18 to 70 years. 2. The pathological type of rectal cancer diagnosed by histopathology is adenocarcinoma. 3. Patients with T3-4 in the eighth AJCC stage or positive regional lymph node and no distant metastasis. 4. Having at least one measurable lesion according to RECIST 1.1. 5. ECOG score 0-1. 6. Expected survival time ≥6 months. 7. Major organ function is normal, that is, meeting the following criteria: blood routine: HB≥90g/L, ANC≥1.5×109/L, PLT≥80×109/L; Biochemical examination of ALB≥30g/L, TBIL≤1.5 ULN, ALT and AST≤2.5 ULN, plasma Cr≤1.5 ULN or creatinine clearance ≥60 ml/min. 8. Subjects volunteered to join the study, signed the informed consent, had good compliance, and cooperated with follow-up. Exclusion Criteria: 1. Patients have had or currently have other malignant tumors within 5 years. 2. Patients allergic or sensitive to any drug in the study protocol. 3. Patients innate or acquired immune deficiency (e.g. HIV infection). 4. The presence of any active, known or suspected autoimmune disease (such as, but not limited to, interstitial pneumonia, uveitis, enteritis, hepatitis, arthritis, nephritis, hypophysitis, hyperthyroidism, hypothyroidism, etc.); The subject had vitiligo. Subjects with asthma require bronchodilators for medical intervention. 5. The presence of active infections requiring systemic treatment. 6. The subject has previously received other PD-1 or PD-L1, or CTLA-4 antibody therapy, or other drug therapy targeting immunoregulatory receptor preparations. 7. Unrelieved toxic effects above CTCAE grade 1 due to any previous treatment, excluding alopecia. 8. Patients with a history of myocardial infarction or stroke, unstable angina pectoris, decompensated heart failure or deep vein thrombosis. 9. Patients with long-term untreated wounds or fractures, major surgical operations or severe traumatic injuries, fractures or ulcers within 4 weeks. 10. Pregnant or lactating women. 11. Patients with liver and kidney dysfunction. 12. Patients with a history of abuse of psychotropic drugs and unable to abstain or patients with mental disorders. 13. Patients who have participated in clinical trials of other drugs within 4 weeks. 14. Patients with concomitant diseases that, in the judgment of the investigator, seriously endanger the patient's safety or affect the patient's completion of the study. 15. The investigator judged that participation in this study was not conducive to the maximum benefit of the subjects.