Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome

Centro Hospitalar De São João, E.P.E.61 enrolled

Overview

This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infarction, Brain Embolism Atrial Fibrillation

Interventions

The presence and rate of MES measured by TCD monitoringOTHER

TCD monitoring within 24 hours from the last known well time. Bilateral M1 segments of middle cerebral artery were insonated at a single depth with 2-MHz transducers secured by a probe-holder.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset. Exclusion Criteria: * use of anticoagulants at stroke onset; prosthetic valves; inadequate temporal bone window; uncooperative patients.

Outcomes

Primary Outcomes

Prevalence of MES

Time frame: Within 24 hours of symptom onset

Poor functional outcome

Time frame: 90-days after stroke

Secondary Outcomes

Ordinal Shift Analysis of mRS scale score