Out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. The aim of this study is to analyze the association between licorice intake and home blood pressure.
For a detailed background, please see Clinical Trials registration number NCT05661721. In brief, out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. In a previous study, the response to licorice intake varied between participants. The aim of this study is to analyze the response of the most "licorice sensitive" quartile of participants from the original study to lower dosages of licorice, corresponding to 20 and 50 milligram och GA daily.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
3
Ecologic sweet licorice pastilles made from Glycyrrhiza glabra grown in Calabria, Italy, with a GA content of 29.9 ±2.0 mg/g.
Cityhälsan Centrum
Norrköping, Östergötland County, Sweden
Systolic home blood pressure
Systolic home blood pressure
Time frame: 3 days before interventions and 28 days during intervention
Diastolic home blood pressure
Diastolic home blood pressure
Time frame: 3 days before interventions and 28 days during intervention
Body weight
Body weight
Time frame: Day 0, 14 and 28
Plasma sodium
Plasma sodium
Time frame: Day 0, 14 and 28
Plasma potassium
Plasma potassium
Time frame: Day 0, 14 and 28
Plasma creatinine
Plasma creatinine
Time frame: Day 0, 14 and 28
Plasma N-terminal pro B-type natriuretic peptide
Plasma N-terminal pro B-type natriuretic peptide
Time frame: Day 0, 14 and 28
Plasma renin
Plasma renin
Time frame: Day 0, 14 and 28
Serum aldosterone
Serum aldosterone
Time frame: Day 0, 14 and 28
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