The Robot-Assisted Laparoscopic Radical Prostatectomy Combined Anterior and Posterior Approach

N/ACompletedNCT06020287

Nanjing University School of Medicine233 enrolled

Overview

The goal of this observational study was to compare the perioperative outcomes, postoperative urinary control rates and positive surgical margin (PSM) rates of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach (AP-RARP) with the Retzius-sparing approach (RS-RARP) and anterior approach (anterior-RARP) in the treatment of prostate cancer. The main question it aims to answer was: • The early therapeutic efficacy of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach Participants has been underwent: * AP-RARP * RS-RARP * anterior-RARP Researchers compared the three groups to see if AP-RARP combines the advantages of anterior and posterior RARP and is a feasible surgical option for the treatment of prostate cancer.

Study Type

OBSERVATIONAL

Enrollment

233

Conditions

Prostatectomy Prostate Neoplasm

Interventions

the robot-assisted laparoscopic radical prostatectomyPROCEDURE

We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.

Eligibility

Sex: MALE

Medical Language ↔ Plain English

Inclusion Criteria: * pathologically diagnosed with prostate cancer by prostate biopsy * underwent robot-assisted laparoscopic surgery * the surgery performed by Weidong Gan * the extended pelvic lymphadenectomy (PLA) is performed on patients with high-risk prostate cancer (PSA≥20 ng/ml or Grade Group 4-5 or clinical stage ≥T2c) and those considered to have a possibility of lymph node metastasis based on imaging evaluation. Exclusion Criteria: * Patients with a clinical and pathological TNM stage ≥T3b and N1 * patients with distant metastasis * urinary incontinence before surgery * received neoadjuvant therapy before surgery

Outcomes

Primary Outcomes

urinary continence

was defined as using 0-1 pad a day

Time frame: 0-6 month after surgery

positive surgical margin

observed whether the tissue cutting in surgery has tumor cell in surgical margin by pathologist

Time frame: 2 weeks after surgery

Secondary Outcomes

operating time

The start time of the operation refers to the time of incision of the skin at the surgical site. The end time of surgery refers to the time when the skin is sutured.

Time frame: the day of the surgery

intraoperative blood loss

Intraoperative bleeding was defined as the sum of blood content in blood gauze, blood content in negative pressure suction bottle and blood clot volume.