Psoriasis and lichen planus often occur at mechanically irritated skin sites (e.g. tight clothing). The investigators would like to investigate this phenomenon in more detail in this study. For this purpose, the skin is specifically irritated at a small and cosmetically favorable site by tearing off scotch tape or rubbing with a wooden spatula. In order to be able to examine the inflammatory processes caused by the irritation more closely, a small skin sample and a skin swab are taken from the irritated area. This skin sample and the swab are repeated after three and fourteen days.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
a small area of skin will be tape-stripped with adhesive tape for up to 40 times and/or rubbed with a wooden spatula until the skin shows a slight erythema
Differences in the transcriptomic profile comparing psoriasis patients with and without induced koebner phenomenon
Transcriptomic profile at all timepoints (reads per 55µm diameter dot)
Time frame: Day 0, Day 3 (optional), Day 14 (optional)
Differences in the proteomic profile comparing psoriasis patients with and without induced koebner phenomenon
Olink multiplex proteomics analysis at all timepoints
Time frame: Day 0, Day 3 (optional), Day 14 (optional)
Characterization of involved immune cells in the skin comparing psoriasis patients with and without induced koebner phenomenon
Imaging mass cytometry (skin biopsies) at all timepoints
Time frame: Day 0, Day 3 (optional), Day 14 (optional)
Characterization of skin mikrobiome
Skin swabs at all timepoints, analyzed by isolation and sequencing of the microbial DNA
Time frame: Day 0, Day 3, Day 14
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.