Sodium, Nocturnal Blood Pressure and Nocturnal Pauses in Breathing

Jesper Norgaard Bech16 enrolled

Overview

A reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease.

A reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease. Patients with hypertension resistant of antihypertensive treatment have a high frequency of non-dipping and obstructive sleep apnoea (OSA). The aim of this project is to analyse the effect of dietary sodium restriction on nocturnal blood pressure and nocturnal pauses in breathing in this patients population.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Sodium Imbalance Nocturnal Blood Pressure Obstructive Sleep Apnea of Adult

Interventions

Dietary sodium restrictionBEHAVIORAL

Selfemployed dietary sodium restriction

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 24h blood pressure \> 130/80 mmHg under antihypertensive treatment with three agent, one of these being diuretic. Blood pressure measurement completed after observed intake of antihypertensive medication. * unchanged antihypertensive treatment for three months * estimated glomerular function \>45 mL/min/1.73 m2 Exclusion Criteria: * Heart failure assessed from NYHA classification (grade 3-4) * Presence of clinically significant peripheral edema * In treatment for obstructive sleep apnea * Chronic obstructive pulmonary disease (FEV1 \<50%) * Antihypertensive therapy that can not be taken once daily * Pregnancy or breastfeeding * Β-albumin \<34 g / l * U-albumin creatinine ratio\> 1000 mg / g * INR\> 1.2 (if marevan treatment: ALAT\> 200) * Gluten allergy (dietary guidelines are not adjusted to this group)

Locations (2)

University clinic in Nephrology and hypertension, Regional Hospital Godstrup

Gødstrup, Herning, Denmark

Department of Medical Research and Medicine, Holstebro Regional Hospital

Holstebro, Denmark

Outcomes

Primary Outcomes

Changes in nocturnal systolic blood pressure

Comparison of blood pressure measured by 24 hour blood pressure measurements at baseline conditions (after two weeks of usual diet) and intervention (after two weeks of dietary sodium restriction)