Pemigatinib for FGF/FGFR Alterations Advanced Pan Solid Tumors

Inclusion Criteria: 1. Age ≥ 18 years old; Gender unlimited 2. Late stage, recurrent, or metastatic solid tumors confirmed by histology or cytology as unresectable by surgery. 3. According to RECIST v1.1, there is at least one measurable lesion. 4. Histological confirmation of FGFR1-3 alterations, including but not limited to amplification, mutation, fusion/rearrangement, etc. 5. After standard treatment, the disease progresses, becomes intolerable, or standard treatment is ineffective, or there is no standard treatment plan. 6. Has not previously used small molecule multi target inhibitors targeting the FGFR pathway (including arotinib, lenvatinib, sorafenib, apatinib, etc.). 7. ECOG physical fitness status is 0-1. 8. Expected survival time\>3 months. 9. Sufficient organ function is required for the subject to meet the following laboratory indicators: 1. In the past 14 days without using granulocyte colony stimulating factor, the absolute value of neutrophils (ANC) ≥ 1.5x10\^9/L. 2. Platelets ≥ 100 without blood transfusion in the past 14 days × 10\^9/L. 3. In the absence of blood transfusion or use of erythropoietin within the past 14 days, hemoglobin\>9g/dL. 4. Total bilirubin ≤ 1.5 × Upper limit of normal value (ULN). Or total bilirubin\>ULN but direct bilirubin ≤ ULN. 5\) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are ≤ 2.5 × ULN (ALT or AST ≤ 5 allowed for patients with liver metastasis) × ULN). 6\) Blood creatinine ≤ 1.5 × ULN and creatinine clearance rate (calculated using Cockcroft Fault formula) ≥ 50 ml/min. 7\) Good coagulation function, defined as international standardized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN. If the subject is undergoing anticoagulant therapy, as long as the PT is within the prescribed range of anticoagulant drugs, it is sufficient. 10. For female subjects of childbearing age, they should undergo a urine or serum pregnancy test with a negative result within 3 days before receiving the first study drug administration (day 1 of cycle 1). If the urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is required. Non reproductive age women are defined as those who have undergone at least one year of menopause or have undergone surgical sterilization or hysterectomy. 11. If there is a risk of conception, all subjects (whether male or female) are required to use contraceptive measures with an annual failure rate of less than 1% throughout the entire treatment period until 120 days after the last study drug administration (or 180 days after the last chemotherapy drug administration). Exclusion criteria: 1. Diagnosed within 5 years prior to the first administration as other malignant diseases outside of the current enrollment diagnosis (excluding basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or carcinoma in situ after radical resection). 2. Previously received selective FGFR inhibitor treatment. 3. Those who have received any other study drug treatment or participated in intervention clinical studies within 28 days before the first administration. Or received anti-tumor drug treatment (including Chinese herbal medicine with anti-tumor indications) within 28 days before the first use of the study drug. 4. Not fully recovered from toxicity and/or complications caused by any intervention measures before starting treatment (i.e. ≤ level 1 or reaching baseline, excluding fatigue or hair loss). 5. Symptomatic central nervous system metastasis and/or cancerous meningitis are known to exist. For brain metastasis subjects who have previously received treatment, if their condition is stable (there is no evidence of imaging progression within at least 4 weeks before the first administration of the trial treatment), repeated imaging examinations confirm no evidence of new brain metastasis or enlargement of existing brain metastasis lesions, and steroid treatment is not required at least 14 days before the first administration of the trial treatment, they can participate in the trial. This exception does not include cancerous meningitis, which should be excluded regardless of its clinical stability. 6. Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. 7. The following laboratory parameters are abnormal: 1. Serum phosphate\>ULN. 2. Serum calcium exceeds the normal range, or when serum albumin exceeds the normal range, the corrected calcium concentration of serum albumin exceeds the normal range. 3. Potassium level\<lower limit of normal value. Potassium levels can be corrected through supplementation during screening. 8. Known history of human immunodeficiency virus (HIV) infection or confirmed positive immune test results. 9. Severe infections with active or poorly controlled clinical conditions. 10. Chest fluid, ascites, or pericardial effusion with obvious clinical symptoms that require drainage treatment. 11. Individuals infected with acute or chronic active hepatitis B or hepatitis C, with hepatitis B virus (HBV) DNA\>2000IU/ml or 10\^4 copies/ml. Hepatitis C virus (HCV) RNA\>10\^3 copies/ml. Hepatitis B surface antigen (HbsAg) and anti HCV antibody were positive at the same time. Those who have undergone nucleotides based antiviral treatment and fall below the above standards can be enrolled in the group. 12. Clinically significant or uncontrolled heart diseases, including unstable angina pectoris, acute myocardial infarction occurring within 6 months prior to first administration, New York Heart Association Class III/IV congestive heart failure, and uncontrolled arrhythmia (allowing subjects with pacemakers or atrial fibrillation and good heart rate control). 13. There are ECG changes or medical histories that researchers believe have clinical significance. Screening QTcF interval\>480 ms, for subjects with indoor conduction block (QRS interval\>120 ms), JTc interval can be used instead of QTc interval (if JTc is used instead of QTc, JTc must be ≤ 340 ms). 14. Uncontrolled hypertension, with systolic blood pressure\>160 mmHg or diastolic blood pressure\>100 mmHg after optimal medical treatment, hypertension crisis or history of hypertensive encephalopathy. 15. Hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh B grade or more severe cirrhosis. 16. Has undergone major surgical procedures (craniotomy, thoracotomy, or laparotomy) within 4 weeks prior to the first dose of study treatment or is expected to require major surgery during the study treatment period. 17. Toxicity and/or major surgical complications have not yet fully recovered before starting treatment. 18. Pregnant or lactating women, or subjects who are expected to conceive or give birth during the study period from screening visits to completion of safety follow-up visits (male subjects up to 90 days after last administration). 19. Received radiotherapy within 4 weeks prior to the first administration of the study drug. The radiation related toxicity of the subject must have fully recovered, and corticosteroid treatment is not required. It is confirmed that radiation pneumonia has been ruled out. For palliative radiotherapy for non-CNS diseases, a 2-week washout period is allowed. 20. Have a history of systemic electrolyte metabolism imbalance caused by calcium and phosphorus metabolism disorders or accompanied by soft tissue ectopic calcification (excluding skin, kidney, tendon, or vascular calcification caused by injuries, diseases, and advanced age without systemic electrolyte metabolism imbalance). 21. Corneal or retinal diseases confirmed to have clinical significance through ophthalmic examination. 22. Any potent CYP3A4 inhibitor (see Appendix A for details) or inducer has been used within 14 days or 5 half-lives before the first administration of the study drug, whichever is shorter. Allow external use of ketoconazole. 23. It is known that there is an allergic reaction to Pemigatinib or its research drug excipients. 24. Unable or unwilling to swallow Pemigatinib or suffering from significant digestive system diseases that may interfere with absorption, metabolism, or excretion. 25. The subject has a history of vitamin D deficiency and needs to supplement vitamin D beyond physiological levels (excluding vitamin D dietary supplements). 26. Other acute or chronic diseases, mental illnesses, or abnormal laboratory test values that may lead to increased risk of study participation or drug administration, or interference with the interpretation of study results, and the inclusion of patients as ineligible to participate in this study based on the investigator's judgment.