The main purpose of this study is to learn about the safety and tolerability of LY3502970 when given to Chinese participants with obesity or overweight with weight-related comorbidities. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. Each enrolled participant will receive LY3502970, or placebo given orally. For each participant, the study will last about approximately 22- and 30-weeks for both cohort 1 and 2, respectively including screening period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
Administered orally.
Administered orally.
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China
West China Hospital Sichuan University
Chengdu, Sichuan, China
Shanghai General Hospital
Shanghai, Songjiang, China
Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module
Time frame: Baseline through Week 18 (Cohort 1) & Week 26 (Cohort 2)
Pharmacokinetics (PK): Maximum Observed Concentration (Cmax) of LY3502970
PK: Cmax of LY3502970
Time frame: Predose on Day 1 up to 116 (Cohort 1) & 172 (Cohort 2) Days postdose
PK: Area Under the Concentration Versus Time Curve From Time 0 to 24 hour Time Point (AUC0-24) of LY3502970
PK: AUC0-24 of LY3502970
Time frame: Predose on Day 1 up to 116 (Cohort 1) & 172 (Cohort 2) Days postdose
Pharmacodynamics (PD): Change From Baseline in Body Weight
PD: Change From Baseline in Body Weight
Time frame: Baseline through 113 Days (Cohort 1) and 169 Days (Cohort 2)
PD: Change From Baseline in Body Mass Index
PD: Change From Baseline in Body Mass Index
Time frame: Baseline through 113 Days (Cohort 1) and 169 Days (Cohort 2)
PD: Change From Baseline in Waist Circumference
PD: Change From Baseline in Waist Circumference
Time frame: Baseline through 113 Days (Cohort 1) and 169 Days (Cohort 2)
PD: Change From Baseline in Fasting Plasma Glucose
PD: Change From Baseline in Fasting Plasma Glucose
Time frame: Baseline through 113 Days (Cohort 1) and 169 Days (Cohort 2)
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