Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement

University of Catania27 enrolled

Overview

A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars. Orthodontic tooth movement induces bone remodeling by various signaling pathways. The variations in miRNAs expression and their impact in inflammation and osteoclastogenesis during the various stages of orthodontic tooth movements is not fully understood. 58 patients requiring asymmetrical upper first premolar extraction for orthodontic purposes have been enrolled for this split-mouth study: the canines to be distalized on the extractive site are considered as the test group, the controlateral canines (on the side without first premolar extraction) areconsidered as normal controls.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Orthodontic Tooth Movement

Interventions

Elastomeric powerchainDEVICE

Canine distalization by engaging the elastomeric power chains onto the canine brackets.

Eligibility

Sex: ALLMin age: 11 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with excellent oral hygiene throughout the study period, * patients requiring asymmetrical maxillary first premolar extraction so monolateral canine retraction will be performed as a part of the treatment, * patients available to come back at the clinic at the times of sample collection. Exclusion Criteria: * poor oral hygiene and/or bleeding on probing, * use medications, steroids or other anti-inflammatory medications, * systemic health problems or smoking.

Locations (1)

AOU Policlinico G. Rodolico

Catania, Italy

Outcomes

Primary Outcomes

miRNAs expression

miRNAs expression in the gingival crevicular fluid by PCR

Time frame: 6 weeks

Data from ClinicalTrials.gov

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