This study will evaluate the efficacy and safety of TACE combined with atezolizumab + bevacizumab in the treatment of unresectable hepatocellular carcinoma, and the treatment patterns of the combination regimen
This study is a multi-center, retrospective and observational real-world study to explore the efficacy, safety and treatment pattern of TACE combined with Atezolizumab + Bevacizumab in unresectable hepatocellular carcinoma. The target population for the planned retrospective analysis of this project is patients who have been diagnosed with unresectable HCC according to the guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2019 Edition) and treated with TACE combined with atezolizumab + bevacizumab.
Study Type
OBSERVATIONAL
Enrollment
200
TACE in combination with atezolizumab + bevacizumab for at least one interval of no more than eight weeks.
Overall survival
Overall survival (OS): defined as the time from the start of the first TACE or atezolizumab + bevacizumab (whichever occurs first) to death due to any cause.
Time frame: 1 year
Progression-Free Survival
Progression-Free Survival (PFS): defined as the time from the start of the first TACE or atezolizumab + bevacizumab (whichever occurs first) to the first occurrence of disease progression or death from any cause.
Time frame: 1 year
Objective response rate
Objective response rate (ORR): defined as the percentage of patients with objective response (CR and PR) from the start of treatment until tumor progression.
Time frame: 1 year
One-year survival rate
One-year survival rate: defined as the percentage of patients who are survival for 1 year from the start of this treatment.
Time frame: 1 year
Immune-TACE PFS
Immune-TACE PFS: defined as the time from the first TACE or atezolizumab bevacizumab (whichever occurs first) to the occurrence of one of the following events (whichever occurs first): * 20% enlargement of intra- or extra-hepatic lesions as assessed by mRECIST or appearance of new extra-hepatic lesions; * TACE refractoriness: insufficient tumor response in the treated tumor for three consecutive times (20% increase by mRECIST); * Deterioration of macrovascular invasion (MVI, defined as tumor invasion of the portal vein or hepatic vein and its branches); * Deterioration of liver function to Child-Pugh C or mALBI 2b; * Death from any cause.
Time frame: 1 year
Disease control rate
Disease control rate (DCR): defined as the proportion of patients achieving complete response (CR) or partial response (PR) or stable disease (SD).
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Time frame: 1 year
Treatment pattern
Treatment pattern: including the timing and frequency of TACE (including its matching chemotherapy regimen), the treatment regimen of atezolizumab + bevacizumab, the sequence of combination therapy and the treatment regimen of the latter line.
Time frame: 1 year