Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio in Juvenile Idiopathic Arthritis

Assiut University50 enrolled

Overview

The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)

The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Juvenile Idiopathic Arthritis

Interventions

fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)DIAGNOSTIC_TEST

measurement of serum albumin, fibrinogen and CRP

Eligibility

Sex: ALLMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects Exclusion Criteria: * Other systemic inflammatory or autoimmune disorders. * History of corticosteroid medication in the last 6 months. * Liver diseases. * Malignancy.

Outcomes

Primary Outcomes

The fibrinogen to albumin ratio

measurement of serum fibrinogen and albumin

Time frame: 3 months

The CRP to albumin ratio

measurement of serum CRP and albumin

Time frame: 3 MONTHS

Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side

correlation of these ratios with JADAS27

Time frame: 3 MONTHS

Data from ClinicalTrials.gov

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