Intravenous Anesthesia by Targeted Controlled Infusion Versus Inhalational Anesthesia on the Surgical Stress Response

Phase 4Active Not RecruitingNCT06024733

Assiut University90 enrolled

Overview

This study aims to compare the effect of total Intravenous anesthesia Target-controlled infusion (TIVA-TCI) with inhalational anesthesia on stress response.

Target-controlled infusion (TCI) techniques have been used to induce and maintain general anesthesia or to provide computer-assisted personalized sedation. Target-controlled infusion (TCI) systems are computer-assisted IV infusion pumps that use pharmacokinetic and pharmacodynamic mathematical modeling to maintain a user-designated target concentration at an effect site (typically the brain). The clinician enters a desired target concentration for an anesthetic or another agent. The computer calculates the amount of the agent required to achieve the target concentration at the effect site and directs an infusion pump to deliver the calculated boluses or infusions. Therefore, TIVA-TCI allows a more stable hemodynamic profile during surgery, prevents long-acting opioid-induced accumulation and allows rapid recovery from general anesthesia. Total intravenous anaesthesia (TIVA) regimen with Propofol is a useful anaesthetic technique, effectively controlling responses to tracheal intubation and intense surgical stimulation, while avoiding Inhalational anaesthetics and allowing rapid emergence from anaesthesia .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Total Intravenous Anesthesia Inhalational Anesthesia Surgical Stress Response Target-controlled Infusion

Interventions

SevofluraneDRUG

patient recieve propofol for induction and sevoflurane for maintenance

Target Controlled InfusionDRUG

target controlled infusion of propofol

Target Controlled Infusion and lidocaineDRUG

patients will receive total intravenous anesthesia with propofol Target Controlled Infusion. At the induction of anesthesia, the patients will receive a bolus of lidocaine 1% 1.5 mg/kg and a continuous infusion of lidocaine 1% 2 mg/kg/h will be associated throughout the procedure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients subjected to lower abdominal cancer surgery. 2. Patients of both sexes 3. body mass index \< 35 kg/m2. 4. Age from 18 to 60 years. 5. ASA, I-II. Exclusion Criteria: 1. Patients with a history of severe cardiovascular or respiratory disease. 2. Severe hepatic, renal, or neurological diseases.

Locations (1)

Assiut University

Asyut, Egypt

Outcomes

Primary Outcomes

The level of the stress response by serum level of insulin-like growth factors

The serum level of insulin-like growth factors will be measured at preoperative, intraoperative after one hour of intubation, at the end of surgery and after extubation, and transfer to the intensive care unit.

Time frame: Intraoperative and 24hours after surgery

Data from ClinicalTrials.gov

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