De-tensioning Patch, in Subjects With Type 1 Diabetes and Lipohypertrophy

Inclusion Criteria: 1. Signed and dated informed consent obtained before any trial-related activities. Trial-related activities are any procedures that would not have been done during normal management of the subject. 2. Subject with type 1 diabetes for at least 3 years 3. One or more palpable lipohypertrophy lesions in the abdominal area, the largest of which has a minimum size of 3.0 cm and a maximum size of 12.0 cm (longest axis) as confirmed by ultrasound. 4. Treated with multiple daily injections (≥3) of insulin for at least 2 years or continuous subcutaneous insulin infusion for at least 1 year. 5. Subject is willing and able to continue same basal insulin during trial participation. 6. Body Mass Index (BMI) 18.5 to 30.0 kg/m², inclusive 7. HbA1c at screening between 6.5% and 9.5% (inclusive) 8. Have clinical laboratory test results within the normal range for the population, or with abnormalities deemed clinically insignificant by the investigator. 9. Considered generally healthy (apart from type 1 diabetes and lipohypertrophy) upon completion of medical history and screening safety assessments, as judged by the Investigator 10. Have venous access sufficient to allow cannulation for blood sampling as required by the protocol Exclusion Criteria: 1. Receipt of any medicinal product in clinical development within 60 days or 5 half-lives (if known) of the medicinal product before randomisation in this trial 2. Any history or presence of cancer, except for a history of basal cell skin cancer or squamous cell skin cancer (as judged by the Investigator) 3. Any history or presence of clinically relevant comorbidity (with the exception of conditions associated with diabetes mellitus), that may place the subject at increased risk as determined by the investigator. 4. Signs of acute illness as judged by the Investigator 5. Any serious systemic infectious disease during four weeks prior to screening, as judged by the Investigator. 6. Aspartate transaminase (AST) and/or Alanine transaminase (ALT) \> 2 times the upper limit of normal 7. Estimated glomerular filtration rate (eGFR)\<60 mL/min 8. Systolic blood pressure \< 90 mmHg or \>160 mmHg and/or diastolic blood pressure \< 50 mmHg or \> 95 mmHg (one repeat test will be acceptable in case of suspected white-coat hypertension) 9. Heart rate at rest outside the range of 50-90 beats per minute. This exclusion criterion also pertains to subjects being on anti-hypertensives. 10. History of severe hypoglycaemia with seizure, coma or requiring assistance of another person during the past 6 months 11. Significant history of alcoholism or drug abuse as judged by the Investigator or consuming more than 24 grams alcohol/day (for males), 12 grams alcohol/day (for females) on average 12. A positive result in the alcohol and/or urine drug screen at the screening visit 13. Tested positive for Hepatitis Bs antigen 14. Tested positive for hepatitis C antibodies. (Presence of hepatitis C antibodies will not lead to exclusion if liver function tests are normal, and a hepatitis C polymerase chain reaction is negative) 15. Positive result to the test for HIV-1/2 antibodies or HIV-1 antigen 16. Have received chronic (lasting \>14 consecutive days) systemic glucocorticoid therapy (excluding topical, intra-articular, and inhaled preparations) in the past 3 months, or have received any non-topical glucocorticoid therapy within 30 days before screening