To collect and evaluate the data of real-world treatment regimen, efficacy, safety and survival information of DLBCL patients with different genetic suptypes
DLBCL is a highly common malignant tumor in Asia. The aim of the study is to observe and explore the clinical information on DLBCL patients with different genetic subtypes and to analyze the clinical characteristics and prognosis of different molecular subtypes of DLBCL. This study is a non-interventional real world, observational study and all registered data are collected from real clinical practice cases. The medical data includes patient demographic, tumor characteristics, laboratory examination, history of treatments, adverse reactions, efficacy results and possible prognostic factors. The results can guide future precision therapy for DLBCL.
Study Type
OBSERVATIONAL
Enrollment
10,000
real world treatment and survival of DLBCL patients in China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGPFS
Progression-free survival (PFS) is defined as the time from the date of first administration to the date of first disease progression or death from any cause, whichever occurs first.
Time frame: Baseline up to data cut-off (Up to approximately 9 years)
ORR
Objective Remission Rate (ORR) is defined as the proportion of patients with complete remission (CR) and partial remission (PR)
Time frame: End of treatment visit (6-8 weeks after last dose on Day 1 of Cycle 6 [Cycle length=21 days]
CRR
Complete Remission Rate (CRR) is defined as the proportion of patients with CR
Time frame: End of treatment visit (6-8 weeks after last dose on Day 1 of Cycle 6 [Cycle length=21 days]
OS
Overall survival (OS) refers to the time from receiving the first dose to death from any cause
Time frame: Baseline up to data cut-off (Up to approximately 9 years)
DOR
Duration Of Remission (DOR) refers to the time from the first CR or PR to the time of the first PD or death from any cause
Time frame: Baseline up to data cut-off (Up to approximately 9 years)
TTR
Time to remission (TTR) refers to the time from recruitment to the time first CR or PR
Time frame: Approximately up to 1 year
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