Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults

Inclusion Criteria: 1. Nonpregnant adults between 18 years and 50 years of age, inclusive. 2. General good health, without significant medical illness, physical examination findings, or significant laboratory abnormalities as determined by the investigator. 3. Demonstrates comprehension of the protocol procedures and knowledge of the trial by passing a written comprehension examination (passing grade \> 70%). 4. Available for the duration of the trial. 5. Willingness to participate in the study and cooperate with the study procedures as evidenced by signing the informed consent document. 6. Persons of childbearing potential must have used effective birth control methods for at least one month prior to vaccination, and agree to continue with 'per label/fully effective use' for the chosen method for the duration of the study (30 days prior to first vaccination until 12 months after first vaccination), from amongst these: * pharmacologic/hormonal contraceptives, including oral, parenteral, subcutaneous, and transcutaneous delivery; * condoms or diaphragm with spermicide; * intrauterine device; * absolute abstinence from heterosexual intercourse as a matter of normal preferred lifestyle; * or must be surgically sterile or have documented menopause, having had no menses at all for at least one full year. All persons of childbearing potential must provide samples for urine and serum pregnancy testing prior to enrollment and prior to vaccination. Pregnancy risk assessment and pregnancy prevention counseling will occur at each point of contact. 7. Willingness to refrain from blood donation during participation in the study and for at least 1 year after receiving the second dose of vaccine. 8. Willingness to refrain from receiving vaccines or other investigational products during the first 90 days of the study after enrollment. Exclusion Criteria: 1. Pregnancy as determined by a positive human choriogonadotropin (ßHCG) test in a person of reproductive capacity. 2. Currently breastfeeding. 3. Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, electrocardiogram (EKG), and/or laboratory studies. 4. Behavioral or cognitive impairment or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol. 5. A history of asthma within the past 5 years, or a current diagnosis of asthma or reactive airway disease associated with exercise, seasonal hay fever or allergic rhinitis. 6. Presence of any febrile illness or symptoms suggestive of a respiratory infection within 2 weeks prior to inoculation. 7. Use of systemic or nasal steroid preparations or immunosuppressive drugs within 30 days prior to vaccination. Topical steroid preparations are permitted. 8. Inhaled bronchodilator or inhaled steroid use within the last year or use after upper respiratory tract infections within the last 5 years. 9. Current or past (in the last 4 weeks) use of intranasal medications (including steroids, decongestants, or hormonal medications), or planning to use them within 28 days of study vaccination. 10. Evidence of current alcohol or illicit drug abuse or addiction. 11. Other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject participating in the trial or would render the subject unable to comply with the protocol. 12. Positive ELISA and confirmatory tests for human immunodeficiency virus (HIV). 13. Positive ELISA and confirmatory test (e.g., recombinant immunoblot assay) for hepatitis C virus (HCV). 14. Positive hepatitis B virus surface antigen (HBsAg) by ELISA. 15. Known immunodeficiency syndrome. 16. Receipt of a live vaccine within 4 weeks or a killed vaccine within 2 weeks prior to receipt of the study vaccine or planned receipt within 90 days after vaccination. (Exception, influenza vaccine may be obtained more than 2 weeks after or prior to the study vaccine). 17. History of a surgical splenectomy. 18. Receipt of blood or blood-derived products (including immunoglobulin \[Ig\]) within 6 months prior to study inoculation. 19. Has participated in another investigational study involving any investigational product within 30 days, or 5 half-lives, whichever is longer, before the first vaccine administration. 20. Body mass index (BMI) \< 18.5 or \>40. 21. Any significant abnormality of the nose or nasopharynx, including recurrent epistaxis and including nasal or sinus surgery. 22. History of Bell's palsy. 23. Has a confirmed SARS-CoV-2 infection or COVID-19 vaccine/booster within 16 weeks prior to enrollment. 24. Unwillingness to have nasopharyngeal (NP) or blood samples saved for future respiratory virus research. 25. Pulmonary function test (PFT) testing for FVC, FEV1, FEV1% and PEF of \<80 or incentive spirometer value \< normal parameters based on gender, age, and height.