Depressive disorders are among the most common psychiatric disorders. However, this disorder is multifaceted, as are its etiological factors, and is not yet fully understood. Within the framework of the P4D study, 1000 patients with depression will be comprehensively examined. In addition to the recording of psychological factors by means of questionnaires and third-party assessments, imaging and electrophysiological procedures (functional and structural MRI, EEG) are used to assess brain structure and function. In addition, blood is drawn from the subjects to analyze these samples for various biological markers (e.g., genetics). Drug level measurements are also performed. The goal is to perform an in-depth characterization (phenotyping) of individuals with a depressive disorder. These findings could be used to individualize and improve therapy for depressive disorders.
Study Type
OBSERVATIONAL
Enrollment
1,000
Remission after 7 weeks of treatment
The Montgomery-Asberg-Depression-Scale (MADRS) is used to measure the severity of depressive symptoms. A score lower 7 is the cut-off.
Time frame: Baseline and Follow-up (Week 7)
Recording of psychometric changes in the clinical course of treatment
A range of psychometric information is collected. These include questionnaires, third party ratings and a cognitive assessment, as well as neuroimaging (functional and structural MRI), neurophysiology (EEG) and polysomnography (PSG).
Time frame: Baseline and Follow-up (Week 7)
Frequency of other concomitant treatments (e.g., additional psychotherapeutic treatment)
Psychotherapy sessions (individual and group therapy) are recorded for 7 weeks. Alternative treatments (e.g. transcranial magnetic stimulation and electroconvulsive therapy) are also recorded.
Time frame: Follow-up (Week 7)
Treatment/study dropout rates
Dropout rates are recorded with reasons.
Time frame: Drop-out rates are collected throughout the data collection period, over two years. Starting at study enrollment of the first subject until complete completion of the last subject.
Attitudes (acceptance, fears, and prejudices) regarding biomarker-guided examinations and technical procedures among the population
Representative population survey
Time frame: The survey will be conducted over a 2-week period in late August / early September 2023.
Patient-doctor relationship
The Patient-Doctor-Relationship-Questionnaire (PDRQ-9) is used to assess the quality of the therapeutic relationship.
Time frame: Baseline and Follow-up (Week 7)
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