The goal of this research study is to investigate the feasibility of implementing a prehabilitation program that aims to improve a patient's physical, nutritional, and sleep health before surgery in an older, at-risk group with esophageal cancer.
This research study is to test whether a novel, 4-week surgical multimodal prehabilitation protocol is feasible in at-risk older adult patients who have previously undergone neoadjuvant chemotherapy or radiotherapy and are scheduled for surgical removal of esophageal cancer. Research study procedures include screening for eligibility, clinic visits, questionnaires, blood tests, and Computed Tomography (CT) scans. Participation in this research study is expected to last 7 months. It is expected about 30 patients will participate in this study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
15
Multimodal prehabilitation program consisting of pre-surgical optimization of nutrition, physical function, and sleep health via individualized plans. Participants will also be supplied with Nestle Impact Advances Recovery Immunonutrition Drink.
Massachusetts General Hospital
Boston, Massachusetts, United States
Enrollment Rate (Feasibility)
Number of eligible patients who enroll in study
Time frame: At screening
Completion Rate (Feasibility)
Defined as the number of patients who complete study procedures.
Time frame: 30 days
Nutrition Compliance Rate (Feasibility)
Comparison of number of nutritional supplements consumed compared to number of nutritional supplements prescribed as determined from daily check-ins. A cut-off value of 80% will be used to indicate compliance.
Time frame: 5 days
Physical Function Compliance Rate (Feasibility)
Comparison of the total minutes of physical function completed compared to the total minutes of physical function prescribed as determined from daily check-ins and wearable device. A cut-off value of 80% will be used to indicate compliance.
Time frame: 30 days
Sleep Health Compliance Rate (Feasibility)
Comparison of the average daily hours of sleep duration, minutes of wake after sleep onset, and variability in sleep timing, achieved compared to prescribed as determined from actigraphy. A cut-off value of 80% will be used to indicate compliance.
Time frame: 30 days
Actigraphy Compliance Rate (Feasibility)
Total daily hours of actiwatch/wearable device wear-time. A cut-off value of 80% will be used to indicate compliance.
Time frame: 30 days
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