tACS for Sensory Motor Recovery After Stroke

N/ANot Yet RecruitingNCT06029062

The University of Texas Health Science Center, Houston14 enrolled

Overview

The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Motor Recovery

Interventions

tACS ShamDEVICE

Sham tACS will applied to the brain through the scalp for 20 minutes.

tACS 10HzDEVICE

10Hz tACS will applied to the brain through the scalp for 20 minutes.

tACS 20HzDEVICE

20Hz tACS will applied to the brain through the scalp for 20 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion/exclusion criteria for stroke subjects Inclusion criteria: 1. Age between 18\~75 years old 2. ≥ 6 months post stroke, medically stable; 3. Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke); 4. Visible finger flexor activation/movement 5. The ability to give consent Exclusion criteria: 1. Patients with visual deficit/neglect; hearing or cognitive impairment; 2. Patients that are currently adjusting tone alternating medications (e.g., baclofen), or 3. Patients received botulinum toxin injection to the arm/fingers \<4 months, or phenol injections \<2 years; 4. Patients with pacemaker, metal implants or supplemental oxygen; 5. Patients who have musculoskeletal disorders, including pain in the affected side 6. Women who are pregnant.

Locations (1)

The University of Texas Health Science Center

Houston, Texas, United States

Outcomes

Primary Outcomes

Block and Box Test (BBT) of Motor functional test

The Box and Block Test (BBT) measures unilateral gross manual dexterity. It is a quick and simple test used with a wide range of populations, including clients with stroke.

Time frame: Change of BBT performance 5 minutes before and 5 minutes after the tACS intervention will be measured.

EEG alpha band and Beta band

Electroencephalography (EEG) is valuable to infer and evaluate the neural interaction. Components of the alpha and beta frequency bands like the sensorimotor rhythm originated from the primary motor cortex and related brain areas reflect human movement. The power of 8-13 Hz alpha and 14-30 Hz beta frequency bands will be used for the classification.

Time frame: Change of EEG alpha band and Beta band 5 minutes before and 5 minutes after the tACS intervention will be measured.

Central Contacts

Sheng Li, MD, Ph.D

CONTACT

(713) 797-7125 sheng.li@uth.tmc.edu

Shengai Li, MS

CONTACT

713-797-7561 shengai.li@uth.tmc.edu

Data from ClinicalTrials.gov

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