Diastolic Function in Myotonic Dystrophy Type 1

Centre d'Investigation Clinique et Technologique 805500 enrolled

Overview

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) . The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Diastolic Dysfunction

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with genetic proven myotonic dystrophy type 1 * who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function Exclusion Criteria: * wall motion basal abnormalities * significant valvular disease

Locations (1)

Hopital Raymond Poincare

Garches, France

Outcomes

Primary Outcomes

mortality

Time frame: 7 years

Secondary Outcomes

Incidence of arrhythmia

Time frame: 7 years

acute heart failure

Time frame: 7 years

Diastolic Function in Myotonic Dystrophy Type 1

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts