Objectives: Systemic autoimmune diseases are chronic diseases characterized by chronic inflammation, vasculopathy, and autoimmune phenomena. Several organ involvements are typical, including the central nervous system. Formerly published investigations emphasize a mild cognitive impairment affecting attention, memory, and complicated solution tasks. However, these symptoms significantly impact patients' routines and quality of life. The study examined the associations between cognitive impairment and clinical parameters regarding systemic autoimmune diseases. Methods: General clinical data, some serum biomarkers including CCl-18, YKL-40, COMP, VEGF, Galectin-3, and Pentraxin as well as results of functional, quality of life, and neuropsychological measures, the Mini-Mental State Examination (MMSE), the Digit Span Forward-Backward, the Trail making A, B and the Digit Symbol tests all were administered.
Study Type
OBSERVATIONAL
Enrollment
400
University of Pécs, Department of Rheumatology and Immunology
Pécs, Hungary
Mini-mental State Examination
Complex Cognitive measure
Time frame: 12 months
The Functional Assessment of Chronic Illness Therapy F
health-related quality of life measure
Time frame: 12 months
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