The main aim of this study is to assess the effects of switching from another biologic to tildrakizumab on patient-reported outcomes and to assess psoriasis intensity, patient's quality of life prior and after switching and the individual rationales for switching biologics.
Study Type
OBSERVATIONAL
Enrollment
50
As provided in real-world clinical practice.
Gesundheitszentrum Citypark Graz
Graz, Styria, Austria
RECRUITINGTreatment Satisfaction Questionnaire for Medication-11 (TSQM-11) Score
TSQM 11-item scale is derived from the TSQM version 1.4, which comprises four domains: global satisfaction, medication effectiveness, convenience, and side effects with scores at each domain ranging from 0 to 100. Higher scores indicating greater satisfaction and lower scores reflecting room for improvement.
Time frame: Baseline, Week 28
World Health Organisation Well-Being Index (WHO-5) Score
The WHO-5 consists of 5-items that measure current mental well-being. Each item is rated on 6-point Likert scale, ranging from 0 (at no the time) to 5 (all of the time). The total raw score, ranging from 0 to 25, is multiplied by 4 to give the final score, with 0 representing the worst imaginable well-being and 100 representing the best imaginable well-being.
Time frame: Baseline up to Week 28
Change from Baseline in absolute Psoriasis Area and Severity Index (PASI) Score
The PASI is a measure of psoriasis and psoriatic arthritis severity that will be assessed at baseline and all follow-up visits for participants with psoriasis or psoriatic arthritis. This common clinical measure selects a representative area of psoriasis for each body region. The intensity of redness, thickness, and scaling of the psoriasis is assessed by the clinician. PASI scores range from 0 to 72, with higher scores indicating worse symptoms.
Time frame: Baseline, Week 4, 16 and 28
Change from Baseline in Physician's Global Assessment (PGA) Score
The PGA is an instrument used in clinical trials to rate the severity of psoriasis. It is a 5-point scale measurement ranging from 0 to 4, where 0- clear, 1- almost clear, 2- mild, 3- moderate and 4- severe; based on degree of plaque thickening, scaling and erythema.
Time frame: Baseline, Week 4, 16 and 28
Change from Baseline in Dermatology Life Quality Index (DLQI) Score
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
The DLQI consists of 10 items addressing the subject's perception of the impact of their skin disease on different aspects of their quality of life. Each item is scored on a 4-point Likert scale (0 = 'not at all / not relevant'; 1 = 'a little'; 2 = 'a lot'; 3 = 'very much'). DLQI scores range from 0 to 30, with higher scores indicating worse quality of life.
Time frame: Baseline, Week 4, 16 and 28
Number of Participants with Individual Reasons for Initiating Switch to Tildrakizumab
Time frame: At Baseline