The goal of this interventional study is to test whether consumption of Wonderlab probiotics with prebiotics could improve obesity and overweight in Chinese people who are aged 25-45 and overweight. The main question it aims to answer is: \- whether the weight of participants can be lost after 10 weeks' intervention 150 participants will be randomized into 3 study groups (50 each group) in the two study sites, who will consume assigned product according to instructions for 10 weeks. Three site visits will be made for each participant and all relevant clinical data will be captured and recorded into CTMS(Clinical Trial Management System) for statistical analysis. Researchers will compare the three groups to conclude whether the Wonderlab study product can improve obesity and overweight over placebo product.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
150
Participants in this arm need to consume one bottle (2g) of this product once a day for 10 weeks
Participants in this arm need to consume one bottle (2g) of this product once a day for 10 weeks
Participants in this arm need to consume one bottle (2g) of this product once a day for 10 weeks
SPRIM Central Lab
Shanghai, Shanghai Municipality, China
Ligang Hospital
Jinhua, Zhejiang, China
Change of Weight
Change of Weight in Kg by Inbody S10 from baseline to 10 weeks
Time frame: baseline day 0, day 70
Blood lipids - Total Cholesterol Level
Blood lipids - Total Cholesterol level of blood test in mmol/L and range of 0.56-17mmol/L for each visit interval
Time frame: baseline day 0, day 35, day 70
Blood Sugar Level
Blood sugar level of blood test in mmol/L and range of 3.9-6.1mmol/L
Time frame: baseline day 0, day 35, day 70
Blood hormone - Leptin level
Blood hormone - Leptin level of blood test in ng/mL and range 0.5-15.2ng/mL
Time frame: baseline day 0, day 35, day 70
Blood hormone - Adiponectin level
Blood hormone - Adiponectin level of blood test in ug/mL and range of 2-37ug/mL
Time frame: baseline day 0, day 35, day 70
Blood inflammation
Blood inflammation (Zonulin, ApoB-48, hsCRP, LPS, sCD14, IL-6, MCP-1, Angptl4)
Time frame: baseline day 0, day 35, day 70
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